Real Madrid are now two points ahead of Barcelona, following a 1-0 win at Espanyol on Sunday night.
Los Blancos came into the game, knowing that a win will see them break away from their rivals, who only played a 2-2 draw with Celta Vigo a day before.
Casemiro scored the only goal of the encounter, latching onto Karim Benzema’s exquisite back heel to finish from a close range.
The win saw Real climbing up to 71 points, with six fixtures left.
Barca host third-placed Atletico Madrid at Camp Nou on Tuesday, before Real Madrid host Getafe on Thursday.